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Xaluritamig 是一種正在研製的新型 T 細胞接合劑免疫療法,可用於治療晚期攝護腺癌。透過在免疫 T 細胞和 STEAP1(一種在攝護腺癌細胞中獨特地過度表達的蛋白質)之間建立免疫突觸,Xaluritamig 旨在啟用免疫系統,對抗攝護腺癌細胞。1-3
以下資源旨在為 XALute 研究工作人員提供支援。
1. Kelly WK, Danila DC, Lin CC, et al. Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study. Cancer Discov. 2024;14(1):76-89. doi: 10.1158/2159-8290
2. Nolan-Stevaux O, Li C, et al. AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer. Cancer Discov. 2024 Jan 12;14(1):90-103. doi: 10.1158/2159-8290
3. Xu M, Evans L, Bizzaro CL, et al. STEAP1-4 (Six-Transmembrane Epithelial Antigen of the Prostate 1-4) and Their Clinical Implications for Prostate Cancer. Cancers (Basel). 2022;14(16):4034. doi: 10.3390/cancers14164034